When an athlete suffered an injury in the past, the main focus of both researchers and clinicians was mainly directed to the affected peripheral structures. However, the current view of the World Health Organization (WHO) shifted this focus towards a more holistic rehabilitation approach with the introduction of the biopsychosocial model. This paradigm shift in patient care became also very present in sports rehabilitation and led to the development of a general Return-To-Sport-Algorithm. Nevertheless, current scientific research within this complex vision has made significant steps forward and contributed to new insights within this domain, but is still in its initial phase. This line of research will explore and document the function of the brain after (sports) injuries and its interactions with fatigue.